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Related Experiment Videos

Prader-Willi syndrome and cycloid psychoses.

W M Verhoeven1, L M Curfs, S Tuinier

  • 1Vincent van Gogh Institute for Psychiatry, Venray, The Netherlands.

Journal of Intellectual Disability Research : JIDR
|February 25, 1999
PubMed
Summary

People with Prader-Willi syndrome (PWS) may be particularly susceptible to cycloid psychosis. This finding suggests a unique psychopathological phenotype in PWS patients requiring specific mood-stabilizing treatments.

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Area of Science:

  • Psychiatry
  • Genetics
  • Clinical Psychology

Background:

  • Prader-Willi syndrome (PWS) is a complex genetic disorder.
  • Psychiatric symptoms in PWS are not fully systematically described.
  • Mood and anxiety disorders are common, with psychosis reported variably.

Observation:

  • This study details six adult male PWS cases with psychiatric symptoms.
  • All cases met diagnostic criteria for cycloid psychosis (ICD-10 F.23.0).

Findings:

  • Subjects with PWS demonstrated a vulnerability to developing cycloid psychosis.
  • This suggests a specific 'psychopathological phenotype' associated with PWS.

Implications:

  • Cycloid psychosis in PWS necessitates targeted psychopharmacological treatment, including mood stabilizers like Lithium.

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  • Further research into the PWS psychopathological phenotype is warranted.