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Epignathus, double pituitary and agenesis of corpus callosum
The Journal of Pathology
|November 1, 1976
Insights
Two infants with epignathus and midline brain abnormalities, including a double pituitary, died shortly after birth. Some infants surviving epignathus surgery may have asymptomatic absent corpus callosum or double pituitary.
Area of Science:
- Developmental biology
- Neuroscience
- Pediatric pathology
Background:
- Epignathus is a rare congenital teratoma originating from the oral or pharyngeal region.
- Midline brain abnormalities, such as absent corpus callosum and pituitary duplication, can occur in complex congenital disorders.
- These anomalies can lead to severe health complications and mortality in neonates.
Abstract:
Two infants from unrelated families died on the 1st day of life with epignathus, duplication of the entire pituitary, infundibulum and sella, and widening or separation of midline structures of the head including absent corpus callosum. We suggest that some infants surviving surgery for large epignathi may have relatively symptomless absent corpus callosum or double pituitary.