Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selective induction of LTP and LTD by postsynaptic [Ca2+]i elevation.

S N Yang1, Y G Tang, R S Zucker

  • 1Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.

Journal of Neurophysiology
|February 26, 1999
PubMed
Summary

Calcium signal patterns determine synaptic plasticity. Brief, high calcium increases trigger long-term potentiation (LTP), while prolonged, modest increases induce long-term depression (LTD) in CA1 pyramidal cells.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Airway Reactance Predicts Static Lung Hyperinflation in Severe Asthma.

Journal of investigational allergology & clinical immunology·2023
Same author

Inhibiting creep in nanograined alloys with stable grain boundary networks.

Science (New York, N.Y.)·2022
Same author

[The role of exosome in the lung diseases].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2020
Same author

[A case of esophagus foreign body misdiagnosed as foreign body aspiration].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2018
Same author

[Brain derived neurotrophic factor enhances the role of mesenchymal stem cells in inhibiting follicular helper T cells].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2018
Same author

[Ventilator-associated pneumonia among premature infants <34 weeks' gestational age in neonatal intensive care unit in China: a multicenter study].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2017

Area of Science:

  • Neuroscience
  • Cellular and Molecular Biology

Background:

  • Synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD), is crucial for learning and memory.
  • Both LTP and LTD in CA1 hippocampal pyramidal cells are initiated by postsynaptic intracellular calcium concentration ([Ca2+]i) elevation.

Purpose of the Study:

  • To investigate how distinct patterns of intracellular calcium elevation can selectively trigger opposing forms of synaptic plasticity (LTP vs. LTD).
  • To elucidate the role of calcium signal dynamics in determining the outcome of synaptic modulation.

Main Methods:

  • Utilized a novel caged calcium compound, nitrophenyl-ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetraacetic acid, to precisely control postsynaptic [Ca2+]i elevation patterns in CA1 pyramidal cells.
  • Electrophysiological recordings to assess synaptic plasticity induction.

Related Experiment Videos

Main Results:

  • Demonstrated that specific temporal patterns of [Ca2+]i elevation selectively induce either LTP or LTD.
  • A brief, high-magnitude [Ca2+]i increase, mimicking typical LTP-inducing stimulation, selectively triggered LTP.
  • A prolonged, modest [Ca2+]i rise reliably induced LTD.

Conclusions:

  • The amplitude and duration of intracellular calcium signals are critical determinants of synaptic plasticity.
  • This finding highlights the sophisticated information encoding capacity of intracellular signaling dynamics.