[Inhibition of corneal neovascularization--the possibility of inhibition by drug administration]

The anti-angiogenic activity of FR 118487, a new synthetic analog of Scolecobasidium arenarium products, was examined in Japanese white rabbit cornea.

We studied both systemic and locally administered FR 118487 (ointment) in a keratoplasty model consisting of corneal neovascularization after implantation of a Wister rat cornea into a rabbit cornea.

Two weeks after the implantation, the maximum length of neovascularization was 3.4 +/- 0.3 mm in control corneas, 0.1 +/- 0.0 mm with systemic FR 118487 administration (10 mg/day) (p < 0.01), 0.1 +/- 0.1 mm with 10% FR118487 ointment (p < 0.001), 1.0 +/- 0.2 mm with 3% FR 118487 ointment (p < 0.001), and 0.9 +/- 0.9 mm with 1% FR 118487 ointment (p < 0.02).

FR 118487 had a significant effect on inhibition of corneal neovascularization.