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Published on: March 30, 2018
Intravascular large cell lymphoma associated with hypoalbuminemia
J Suzumiya1, K Ohshima, M Kanda
1First Department of Pathology, School of Medicine, Fukuoka University, Japan. suzumiya@msat.fukuoka-u.ac.jp
Leukemia & Lymphoma
|February 26, 1999
Summary
This case report details a rare intravascular large B-cell lymphoma diagnosed postmortem in a 71-year-old woman. The lymphoma cells caused severe edema by obstructing vessels and increasing protein breakdown.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Intravascular large B-cell lymphoma (ILBCL) is a rare hematologic malignancy.
- ILBCL is characterized by the proliferation of malignant B-cells within blood vessels.
Observation:
- A 71-year-old Japanese woman presented with severe anasarca (generalized edema) and hypoalbuminemia (low blood albumin levels).
- The patient's condition was diagnosed as ILBCL postmortem.
Findings:
- Postmortem examination revealed intravascular proliferation of large B-cells.
- The severe edema was attributed to vascular and/or lymphatic obstruction by the lymphoma cells.
- Increased catabolism induced by tumor proliferation may have also contributed to hypoalbuminemia.
Implications:
- This case highlights the diagnostic challenges of ILBCL, particularly when presenting with non-specific symptoms like anasarca.
- Understanding the mechanisms of edema in ILBCL is crucial for potential future therapeutic strategies.
- Further research into ILBCL pathogenesis and clinical manifestations is warranted.
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