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Risk of testicular cancer in subfertile men: case-control study
1Centre for Research in Health and Social Statistics, Danish National Research Foundation, Sejrogade 11, DK-2100 Copenhagen O, Denmark.
Objective:
To evaluate the association between subfertility in men and the subsequent risk of testicular cancer.
Design:
Population based case-control study.
Setting:
The Danish population.
Participants:
Cases were identified in the Danish Cancer Registry; controls were randomly selected from the Danish population with the computerised Danish Central Population Register. Men were interviewed by telephone; 514 men with cancer and 720 controls participated.
Outcome Measure:
Occurrence of testicular cancer.
Results:
A reduced risk of testicular cancer was associated with paternity (relative risk 0.63; 95% confidence interval 0.47 to 0.85). In men who before the diagnosis of testicular cancer had a lower number of children than expected on the basis of their age, the relative risk was 1.98 (1.43 to 2.75). There was no corresponding protective effect associated with a higher number of children than expected. The associations were similar for seminoma and non-seminoma and were not influenced by adjustment for potential confounding factors.
Conclusion:
These data are consistent with the hypothesis that male subfertility and testicular cancer share important aetiological factors.