[Effect of the beta-receptor-blocker prindolol on renal hypertension (author's transl)]

Under standardised conditions Prindolol-therapy (3 X 5 mg/die) was carried out in patients with renal hypertension in addition to the preexisting anti-hypertensive treatment during a period of 8 weeks. After administration of Prindolol for 4 and 8 weeks a significant (p less than 0.05) reduction of blood pressure (systolic and diastolic) was observed. 3 weeks after discontinuing the Prindolol-therapy blood pressure rose again, but it clearly remained below pretreatment level. Peak values of blood pressure during the day were markedly lowered. Antihypertensive efficacy was age-related. Lowering of blood pressure occurred in 70% of our patients. There existed no relation between plasma-renin-level and reactivity of the patients to the antihypertensive effect of Prindolol. Renal function (creatine-clearance) did not alter significantly by Prindolol-treatment.