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NMR tools for biotechnology.

P A Keifer1

  • 1Varian NMR Instruments 3120 Hansen Way D-298 Palo Alto CA 94304-1030 USA. paul.keifer@nmr.varian.com

Current Opinion in Biotechnology
|February 27, 1999
PubMed
Summary
This summary is machine-generated.

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Nuclear Magnetic Resonance (NMR) spectroscopy is advancing with new hardware and techniques. These innovations enable the analysis of complex samples without chromatography, expanding NMR

Area of Science:

  • Analytical Chemistry
  • Spectroscopy
  • Organic Chemistry

Background:

  • Nuclear Magnetic Resonance (NMR) spectroscopy is a vital analytical technique.
  • Continuous innovation is essential for expanding NMR's capabilities.
  • Existing methods face challenges with complex or limited sample types.

Purpose of the Study:

  • To review recent advancements in NMR spectroscopy.
  • To categorize new developments in hardware, techniques, and applications.
  • To highlight the impact of these advances on analyzing challenging samples.

Main Methods:

  • Review of recent literature on NMR spectroscopy.
  • Categorization of developments into hardware, techniques, and applications.
  • Focus on techniques for spectral editing and mixture analysis without separation.

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Main Results:

  • Hardware advancements include flow NMR and new probe designs.
  • New techniques allow NMR spectral editing of mixtures without chromatography.
  • Novel applications enable analysis of complex mixtures, libraries, bound drugs, unstable, small, and heterogeneous samples.

Conclusions:

  • NMR spectroscopy remains a dynamic research field.
  • Recent developments significantly enhance the power and scope of NMR analysis.
  • These tools provide new solutions for analyzing previously intractable samples.