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The past and future of structure databases.

¹Department of Chemistry Rutgers University 610 Taylor Road Piscataway NJ 08854-8087 USA. berman@rcsb.rutgers.edu

Current Opinion in Biotechnology

|February 27, 1999

Summary

The Protein Data Bank was the main source for macromolecular information. Now, diverse databases offer new ways to organize and access structural data for proteins and other molecules.

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Area of Science:

Structural biology
Bioinformatics
Molecular databases

Background:

The Protein Data Bank (PDB) historically served as the primary repository for biological macromolecular structure data.
Advancements in data organization have led to the development of diverse structural databases.

Purpose of the Study:

To highlight the evolution of macromolecular information resources.
To introduce the variety of currently available structural databases.

Main Methods:

Review of existing macromolecular databases.
Classification of databases based on data organization and focus.

Main Results:

The Protein Data Bank (PDB) is no longer the sole source of structural information.
A variety of databases now exist, organizing data by overall structure, specific features, or protein families.

Conclusions:

The landscape of biological macromolecular databases has diversified significantly.
Researchers have access to more specialized and organized structural information than ever before.

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