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Genes regulating MHC class I processing of antigen

P M van Endert1

  • 1INSERM U25 Hôpital Necker, Paris, France. vanendert@necker.fr.

Current Opinion in Immunology
|February 27, 1999
PubMed

The principal pathway of antigen processing that is associated with MHC class I involves three main steps: cytosolic peptide generation, peptide transport into the endoplasmic reticulum and peptide assembly with class I molecules. Recent advances suggest that additional cytosolic proteases complement the proteasome as a source of antigenic peptides. Peptide assembly involves several novel cofactors - including the proteins tapasin and ERp57, which may be important for stabilisation of empty class I molecules as well as quality control after peptide binding. Finally, genetic evidence suggests an important influence of an unidentified gene, in the MHC complex, on MHC class I processing.

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