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Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
Published on: December 15, 2010
Ultrasound microneurosurgery
R Ramazanov1, O N Dreval, O V Akatov
1Department of Neurosurgery, Russian Medical Academy of Postgraduate Training, Moscow, Russia.
Abstract:
This work focuses on the use of an ultrasound neurosurgical unit which includes frequency generator and acoustic converter with different types of surgical attachments according to the surgical peculiarity. These attachments were designed to be used for ultrasonic resection, ultrasonic aspiration, ultrasonic disintegration and other applications. High cutting ability, possibility of local disintegration, specific hemostatic effects and other benefits of ultrasonic surgical tools (in the experimental level) were behind the efforts to create the ultrasound microneurosurgical unit with different attachments of cutting, disintegration, aspiration and separation tools. We used the ultrasound microneurosurgical unit during 299 operations involving meningiomas; acoustic neurinomas; gliomas; hordomas; pituitary adenomas; craniopharyngiomas; tuberculoma; paroxysmal pain in the patients with brachial plexus injuries, facial pain, phantom limb pain, intercostal neuralgia, post-mastectomy syndrome, syringomyelia and tumors of nerve trunks. The experience of using the surgical instruments based on ultrasound oscillation of the working edge showed their high efficiency and good perspective in experimental research as well as in practical application in different ramifications of surgery.

