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Updated: Aug 19, 2026

HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
Published on: July 20, 2016
Parathyroid hormone-related protein (PTH-rP)-associated hypercalcemia in a patient with an atypical chronic
L T Vlasveld1, P Pauwels, A A Ermens
1Department of Internal Medicine, Diaconessenhuis, BM Eindhoven, The Netherlands.
Abstract:
We describe a patient with an atypical chronic lymphocytic leukemia (CLL) of the mixed cell type with a hypercalcemia due to parathyroid hormone-related protein production by the malignant B cells. On regard of the elevated serum calcium level without overt lytic bone lesions we found elevated serum levels of PTH-rP and demonstrated the presence of PTH-rP on the malignant lymphocytes. PTH-rP-related hypercalcemia in CLL is very rare. The role in PTH-rP in humoral hypercalcemia of malignancy is discussed.
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