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Stability of captopril in invert sugar solution
1Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore.
Objective:
To assess the stability of captopril in different concentrations of invert sugar solution and to verify the hypothesis that the antioxidant effect of invert sugar can inhibit captopril's oxidative degradation.
Method:
Captopril 1 mg/ml formulations were prepared in 0% (Milli-Q water), 1%, 10%, 30% and 85% w/v of invert sugar and stored at 5 C. The formulations were sampled at intervals up to 30 days for assay of captopril using a stability-indicating high-performance liquid chromatographic method.
Results:
Captopril in formulations containing low concentrations (1%, 10%, 30% w/v) of invert sugar was significantly less stable than in the control formulation (captopril 1 mg/ml in Milli-Q water). In contrast, captopril in a formulation containing 85% w/v invert sugar was substantially more stable than in the control.
Conclusion:
Captopril formulated in a solution of 85% w/v invert sugar is stable for at least 2 weeks when stored at 5 degrees C.