Stability of captopril in invert sugar solution

Area of Science:

• Pharmaceutical Sciences
• Drug Stability
• Formulation Development

Background:

• Captopril is susceptible to oxidative degradation.
• Invert sugar is known for its antioxidant properties.
• Understanding drug stability in various formulations is crucial for effective pharmaceutical development.

Purpose of the Study:

• To evaluate the stability of captopril in different concentrations of invert sugar solutions.
• To investigate the potential of invert sugar's antioxidant properties to inhibit captopril degradation.

Main Methods:

• Captopril (1 mg/ml) formulations were prepared using Milli-Q water (0%) and invert sugar solutions (1%, 10%, 30%, 85% w/v).
• Formulations were stored at 5°C for up to 30 days.
• Captopril concentration was determined using a stability-indicating high-performance liquid chromatographic method at regular intervals.

Main Results:

• Captopril stability decreased in low invert sugar concentrations (1%, 10%, 30% w/v) compared to the control.
• Captopril exhibited significantly enhanced stability in 85% w/v invert sugar solution.
• The results indicate a concentration-dependent effect of invert sugar on captopril stability.

Conclusions:

• Captopril demonstrates good stability in 85% w/v invert sugar solution for at least two weeks when stored at 5°C.
• High concentrations of invert sugar may offer a protective effect against captopril oxidative degradation.
• Further research could explore the precise mechanism of antioxidant action and optimal formulation parameters.