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Routine patch testing with the sesquiterpene lactone mix in Europe: a 2-year experience. A multicentre study of the
E Paulsen1, K E Andersen, F M Brandão
1Department of Dermatology, Odense University Hospital, Denmark.
Contact Dermatitis
|February 27, 1999
Summary
The sesquiterpene lactone (SL) mix is a safe and valuable allergen for standard patch testing in Europe. Its inclusion helps identify Compositae-sensitive patients, with positive reactions indicating current relevance for many.
Area of Science:
- Dermatology
- Allergology
- Toxicology
Background:
- Sesquiterpene lactones (SLs) are common allergens found in plants, often causing allergic contact dermatitis.
- Standard patch testing aids in diagnosing contact allergies, but the screening value of SL mix requires evaluation.
Purpose of the Study:
- To assess the screening value of the sesquiterpene lactone (SL) mix in European patch test series.
- To describe the epidemiological and clinical characteristics of patients sensitive to Compositae.
Main Methods:
- Inclusion of SL mix 0.1% pet. in standard patch tests across 11 European clinics.
- Testing of 10,695 patients and analysis of positive reactions, patient demographics, suspected sensitizers, and clinical presentation.
Main Results:
- 106 patients (1%) showed positive reactions to SL mix, with 74% being currently or previously relevant.
- Prevalence varied (0.1-2.7%); garden plants were major suspected sensitizers, affecting hands, forearms, face, or causing widespread eczema.
- Cross-reactivity with perfume/colophony was noted in over a third of positive cases.
Conclusions:
- The SL mix is a safe allergen with a low incidence of irritant reactions and active sensitization.
- The prevalence of positive reactions supports the continued use of SL mix in standard patch testing for identifying Compositae-sensitive individuals.