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Sensitization to thimerosal in atopic children.

A Patrizi1, L Rizzoli, C Vincenzi

  • 1Department of Clinical and Experimental Medicine, University of Bologna, Italy.

Contact Dermatitis
|February 27, 1999
PubMed
Summary
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Thimerosal in vaccines can trigger eczema flare-ups in sensitized infants with atopic dermatitis (AD). However, these children can safely complete their vaccination schedules with precautions.

Area of Science:

  • Pediatrics
  • Immunology
  • Dermatology

Background:

  • Thimerosal, an organic mercurial compound, is a common preservative in vaccines and other medical solutions.
  • Atopic dermatitis (AD) is a chronic inflammatory skin condition often associated with hypersensitivity.
  • Vaccine preservatives like thimerosal have been investigated for potential roles in immune-related conditions.

Purpose of the Study:

  • To investigate the clinical effects of thimerosal in infants with atopic dermatitis (AD).
  • To assess the frequency of thimerosal sensitization in children with AD.
  • To determine the safety of completing mandatory vaccinations in thimerosal-sensitized children.

Main Methods:

  • Case study of 5 infants (7-28 months) with diagnosed AD experiencing post-vaccination exacerbations.

Related Experiment Videos

  • Clinical observation of cutaneous lesions (nummular eczema).
  • Patch testing with serial dilutions of thimerosal in petrolatum.

    • Main Results:

    • All 5 infants showed positive patch test reactions to thimerosal, indicating sensitization.
    • Three infants reacted to lower concentrations (0.01% and 0.05% pet.).
    • Despite sensitization, all children completed their vaccination series without further AD exacerbations over a 2-year follow-up.

    Conclusions:

    • Confirms a high frequency of thimerosal sensitization in children with AD.
    • Suggests that vaccination can precipitate clinical symptoms in sensitized individuals.
    • Thimerosal sensitization does not preclude the completion of essential childhood vaccinations.