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Related Experiment Videos

Isotope ratio determination in boron analysis.

R N Sah1, P H Brown

  • 1Department of Pomology, University of California, Davis, USA.

Biological Trace Element Research
|March 2, 1999
PubMed
Summary
This summary is machine-generated.

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Accurate boron isotope ratio determination is crucial. While high-resolution plasma-source mass spectrometry offers convenience, sample preparation and analytical methods remain key limitations for precision and accuracy.

Area of Science:

  • Analytical Chemistry
  • Geochemistry
  • Environmental Science

Background:

  • Boron (B) isotope ratios are traditionally measured using thermal ionization mass spectrometry (TIMS) and secondary ion mass spectrometry (SIMS).
  • These methods, while precise, involve time-consuming sample preparation and potential interferences.
  • Plasma-source mass spectrometry (MS) emerged as a faster alternative, with inductively coupled plasma mass spectrometry (ICP-MS) becoming popular for its speed and convenience.

Purpose of the Study:

  • To review the current state of instrumental capabilities for boron isotope ratio determination.
  • To identify the primary limitations hindering accurate and precise B isotope ratio measurements.
  • To discuss the impact of sample preparation, introduction, and analytical methodology on B isotope analysis.

Main Methods:

Related Experiment Videos

  • Comparison of traditional methods (TIMS, SIMS) with plasma-source MS (ICP-MS).
  • Evaluation of different sample preparation techniques including alkali fusion, wet-ashing, microwave digestion, and ion-exchange separation.
  • Discussion of challenges such as analyte loss, isotope fractionation, difficult matrices, and memory effects.

Main Results:

  • Quadrupole ICP-MS offers speed and convenience but lower precision than TIMS/SIMS.
  • Newer high-resolution ICP-MS instruments show improved sensitivity and precision.
  • Sample preparation methods like alkali fusion and wet-ashing with HF can lead to B loss and fractionation.
  • Closed-vessel microwave digestion can cause spectral interference, and ion-exchange resins may induce fractionation and memory effects.

Conclusions:

  • High-resolution ICP-MS is poised to become the preferred method for B isotope ratio determination due to its throughput and convenience.
  • Despite instrumental advancements, precision and accuracy are predominantly limited by sample preparation, introduction, and analytical methodology.
  • Addressing analyte loss, isotope fractionation, matrix effects, and memory effects during sample handling is critical for reliable B isotope analysis.