Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic-epigenetic interactions (meQTLs) in orofacial clefts etiology.

Molecular genetics and genomics : MGG·2026
Same author

Multiancestral GWAS of Dental Malocclusion Identifies Multiple Risk Loci.

Journal of dental research·2026
Same author

Epigenetic Signatures in Monozygotic and Dizygotic Twins Discordant for Orofacial Clefts.

medRxiv : the preprint server for health sciences·2026
Same author

Genetic-epigenetic interactions (meQTLs) in orofacial clefts etiology.

medRxiv : the preprint server for health sciences·2025
Same author

Multiancestry Genome-Wide Association Study of Early Childhood Caries.

Journal of dental research·2024
Same author

Oral Disease and Atherosclerosis May Be Associated with Overlapping Metabolic Pathways.

JDR clinical and translational research·2024

Related Experiment Video

Updated: Jul 13, 2026

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
05:32

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos

Published on: December 7, 2018

Segregation analysis of attention deficit hyperactivity disorder.

B S Maher1, M L Marazita, H B Moss

  • 1Cleft Palate-Craniofacial Center, School of Dental Medicine, University of Pittsburgh, Pennsylvania 15261, USA.

American Journal of Medical Genetics
|March 2, 1999
PubMed
Summary

Genetic factors significantly influence attention deficit hyperactivity disorder (ADHD) symptom severity. This study suggests ADHD is an extreme manifestation of a heritable, continuous trait, with sex-dependent transmission patterns observed in affected families.

More Related Videos

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
05:48

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients

Published on: June 12, 2020

Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)
10:02

Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)

Published on: March 12, 2020

Related Experiment Videos

Last Updated: Jul 13, 2026

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
05:32

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos

Published on: December 7, 2018

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
05:48

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients

Published on: June 12, 2020

Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)
10:02

Event Related Potentials (ERPs) and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder (ADHD)

Published on: March 12, 2020

Area of Science:

  • Genetics
  • Psychiatry
  • Behavioral Science

Background:

  • Attention Deficit Hyperactivity Disorder (ADHD) is a complex neurodevelopmental disorder with suspected genetic underpinnings.
  • Understanding the mode of inheritance and genetic influences is crucial for developing targeted interventions.
  • Previous research indicates a significant heritable component, but the specific transmission patterns require further elucidation.

Purpose of the Study:

  • To investigate the role of genetic and environmental factors in the variability of Attention Deficit Hyperactivity Disorder (ADHD) symptom counts.
  • To determine the mode of inheritance for ADHD, treating symptom count as a quantitative trait.
  • To examine sex-dependent effects and covariate influences (socioeconomic status) on ADHD symptom transmission.

Main Methods:

  • Segregation analysis was performed on 495 nuclear families ascertained for paternal substance abuse.
  • ADHD symptom count (DSM-III-R) was analyzed as a quantitative trait using class A and D regressive models.
  • Analyses were conducted on the full dataset and a subgroup of 130 families with at least one diagnosed member, assessing sex dependence and covariates.

Main Results:

  • Analysis of the full dataset suggested a transmissible, non-Mendelian major effect influencing ADHD symptom count.
  • In a subgroup of families with diagnosed ADHD, a sex-dependent Mendelian codominant model provided the best fit, rejecting other models.
  • Covariate effects did not significantly improve model fit in the subgroup, indicating strong genetic influence.

Conclusions:

  • The findings support Mendelian transmission of ADHD symptom count in a clinically relevant population.
  • ADHD appears to be an extreme manifestation of an underlying heritable, continuous trait.
  • Sex-dependent genetic factors play a significant role in the transmission of ADHD symptoms.