Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonparametric simulation-based statistical analyses for bipolar affective disorder locus on chromosome 21q22.3.

J B Kwok1, L J Adams, J A Salmon

  • 1Garvan Institute of Medical Research, Sydney, New South Wales, Australia.

American Journal of Medical Genetics
|March 2, 1999
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Parental but not child reports of affective lability in offspring predict conversion to bipolar disorder in youth at increased genetic risk.

Journal of affective disorders·2026
Same author

The effects of anthropogenic sound on behaviour and physiology in female Port Jackson sharks Heterodontus portusjacksoni (Elasmobranchii).

Marine pollution bulletin·2025
Same author

Longitudinal changes in neurocognitive functioning over two years in young people at increased genetic risk of bipolar disorder.

Journal of affective disorders·2025
Same author

Axonal damage and astrocytosis are biological correlates of grey matter network integrity loss: a cohort study in autosomal dominant Alzheimer disease.

medRxiv : the preprint server for health sciences·2023
Same author

Hippocampal cingulum white matter increases over time in young people at high genetic risk for bipolar disorder.

Journal of affective disorders·2022
Same author

The 'difficult-to-treat depression' and the 'response paradigm' models: Implications and relevance to patient management.

The Australian and New Zealand journal of psychiatry·2021

This study investigated a potential genetic link for bipolar affective disorder (BAD) on chromosome 21q22.3. Some analyses supported linkage, particularly in one family, suggesting a susceptibility locus for BAD.

Area of Science:

  • Genetics
  • Psychiatry
  • Human Genetics

Background:

  • Previous research identified a candidate locus for bipolar affective disorder (BAD) on chromosome 21q22.3.
  • Replication studies are crucial for validating genetic associations in complex disorders.

Purpose of the Study:

  • To replicate the putative bipolar affective disorder (BAD) locus on chromosome 21q22.3 in Australian pedigrees.
  • To assess the cosegregation of microsatellite markers with BAD in affected families.

Main Methods:

  • Analysis of 12 Australian BAD pedigrees using six microsatellite markers.
  • Application of nonparametric linkage analysis methods including SimAPM, SimIBD, GENEHUNTER, and MFLINK.
  • Calculation of combined LOD scores and analysis of individual family data.

Related Experiment Videos

Main Results:

  • Positive results for linkage were observed for markers PFKL (P < 0.001) and D21S198 (P = 0.007) using SimAPM.
  • SimIBD analysis also showed significant linkage for PFKL (P < 0.001).
  • One family (family 17) showed suggestive linkage (LOD > 1.41) in the PFKL-D21S198 region, despite overall negative combined LOD scores.

Conclusions:

  • This study provides additional evidence supporting a suggestive linkage of a susceptibility locus for bipolar affective disorder (BAD) on chromosome 21q22.3.
  • The findings highlight the complexity of genetic contributions to BAD and the need for further investigation.