Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Iron chelation therapy for malaria: a review.

G F Mabeza1, M Loyevsky, V R Gordeuk

  • 1Department of Medicine, University of Zimbabwe Medical School, Harare.

Pharmacology & Therapeutics
|March 2, 1999
PubMed
Summary

Iron chelators show promise as new antimalarial drugs. Both iron(III) and iron(II) chelators exhibit activity against malaria parasites, with iron chelation therapy demonstrating clinical efficacy in human malaria cases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distribution of DMT 1 within the human glandular system.

Histology and histopathology·2003
Same author

Pulmonary actinomycosis.

The European respiratory journal·2003
Same author

Atorvastatin suppresses interferon-gamma -induced neopterin formation and tryptophan degradation in human peripheral blood mononuclear cells and in monocytic cell lines.

Clinical and experimental immunology·2003
Same author

Assessing menstrual cycles with urinary hormone assays.

American journal of physiology. Endocrinology and metabolism·2002
Same author

The Koebner phenomenon: review of the literature.

Journal of the European Academy of Dermatology and Venereology : JEADV·2002
Same author

Oral terbinafine in the treatment of onychomycosis: a comparison of continuous and extended-pause regimens.

Journal of the European Academy of Dermatology and Venereology : JEADV·2002

Area of Science:

  • Medicinal Chemistry
  • Parasitology
  • Pharmacology

Background:

  • Malaria remains a significant global health challenge, necessitating novel therapeutic strategies.
  • Existing treatments face challenges, driving research into new antimalarial agents.

Purpose of the Study:

  • To investigate the antimalarial potential of iron chelators.
  • To explore the mechanisms of action for different types of iron chelators against malaria parasites.

Main Methods:

  • In vitro screening of iron(III) and iron(II) chelators for antimalarial activity.
  • Evaluation of antimalarial compounds in animal models of plasmodial infection.
  • Assessment of clinical efficacy of iron chelation therapy in human malaria.

Main Results:

Related Experiment Videos

  • Iron(III) chelators demonstrated in vitro antimalarial activity, likely by depriving the parasite of essential iron.
  • Iron(II) chelators also showed antimalarial effects, potentially through the formation of toxic iron complexes.
  • Several iron(III)-chelating compounds were effective in animal models.
  • Desferrioxamine, an iron chelation therapy, showed clinical activity in uncomplicated and severe human malaria.

Conclusions:

  • Iron chelation represents a viable therapeutic strategy for malaria.
  • Further development of iron chelators could lead to new and effective antimalarial drugs.