[Characteristics of kidney lesions in patients with hemophilia]

Renal enzymuria was measured in hemophiliacs: enzymes of tubular epithelium, associated with cytomembrane, lysosomal, cytosolic, marker of glomerular defect. The enzymological markers indicated impairment of nephron tubular component in all the examinees. Patients with hematuria had also defects in glomerular apparatus. A direct relationship existed between the severity of calciuria and activity of membrane-associated enzymes of canalicular epithelium.