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Related Experiment Videos

[Chronic inflammatory bowel disease and pregnancy. Case control study].

I Larzilliere1, P Beau

  • 1Service d'Hépato-Gastroentérologie et Nutrition Artificielle, Hôpital Jean-Bernard, CHU, Poitiers.

Gastroenterologie Clinique Et Biologique
|March 3, 1999
PubMed
Summary

Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, negatively impacts pregnancy outcomes. Women diagnosed with IBD often experience higher rates of underweight offspring and preterm births, affecting fetal health.

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Area of Science:

  • Gastroenterology and Obstetrics/Gynecology
  • Reproductive Health
  • Chronic Disease Management

Context:

  • Inflammatory bowel disease (IBD) encompasses chronic inflammatory conditions of the gastrointestinal tract, primarily ulcerative colitis and Crohn's disease.
  • Pregnancy in women with IBD presents unique challenges due to the systemic inflammatory nature of the disease and potential treatment effects.
  • Understanding the impact of IBD on maternal and fetal outcomes is crucial for optimizing prenatal care and management strategies.

Purpose:

  • To investigate the influence of inflammatory bowel disease (IBD) on pregnancy progression and fetal well-being.
  • To compare pregnancy and fetal outcomes in women with ulcerative colitis and Crohn's disease with control groups.
  • To identify specific risks associated with IBD during pregnancy, such as birth weight and prematurity.

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Summary:

  • A study compared 150 pregnancies in 72 women with IBD (ulcerative colitis or Crohn's disease) to 150 control pregnancies.
  • In ulcerative colitis, a higher rate of underweight offspring was observed when pregnancy occurred after IBD diagnosis.
  • Crohn's disease during pregnancy was associated with a higher mean age at first pregnancy, lower mean birth weight, and increased preterm birth rates compared to pregnancies before diagnosis.

Impact:

  • The findings indicate that both ulcerative colitis and Crohn's disease can adversely affect pregnancy and fetal outcomes.
  • This research highlights the need for specialized obstetric care for pregnant women with IBD.
  • Early diagnosis and management of IBD may be crucial for improving pregnancy results and reducing fetal complications.