[Imaging in pediatric Herpes simplex virus type I encephalitis]

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S Panisset1, C Adamsbaum, B Heron

  • 1Service de Radiologie, Hôpital Saint Vincent de Paul, Paris.

Journal De Radiologie
|March 3, 1999
PubMed

Insights

Radiological features of herpes simplex virus 1 encephalitis in children are described. Hemorrhagic lesions and unilateral thalamic involvement appear after 4 days, correlating with clinical recurrence.

Area of Science:

  • Pediatric Neurology
  • Neuroradiology
  • Infectious Diseases

Background:

  • Herpes simplex virus 1 encephalitis (HSVE) is a rare but severe neurological infection.
  • Radiological findings in pediatric HSVE are not well-documented, particularly in early disease stages.

Purpose of the Study:

  • To characterize the spectrum of radiological findings in children diagnosed with herpes simplex virus 1 encephalitis.
  • To correlate imaging findings with disease progression and clinical presentation.

Main Methods:

  • Retrospective analysis of imaging studies (CT and MRI) in 10 children with confirmed HSVE.
  • Evaluation of imaging findings in relation to the timing of clinical presentation and disease course.

Main Results:

  • Initial CT scans were normal in 50% of cases; low densities and hemorrhagic lesions were present in nearly 50%.
  • Hemorrhagic lesions were observed in all patients after 4 days of infection.
  • Unilateral thalamic involvement was noted in 50% of cases, associated with clinical recurrence.

Conclusions:

  • Early CT scans may not reveal abnormalities in pediatric HSVE.
  • Hemorrhagic lesions and thalamic involvement are significant findings in later stages of HSVE.
  • The clinical significance of thalamic involvement in HSVE requires further investigation.
Abstract

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