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Pseudogout attack associated with chronic thyroiditis and Sjögren's syndrome.
1Department of Internal Medicine, Mishuku Hospital, Tokyo.
Internal Medicine (Tokyo, Japan)
|March 3, 1999
Summary
Thyroid hormone replacement therapy can trigger pseudogout attacks. This case highlights a potential link between this therapy, pseudogout, and Sjögren's syndrome in patients with chronic thyroiditis.
Area of Science:
- Endocrinology
- Rheumatology
- Internal Medicine
Background:
- Chronic thyroiditis management often involves levothyroxine sodium replacement therapy.
- Levothyroxine dosage adjustments are common to achieve euthyroid state.
- Thyroid dysfunction and autoimmune conditions frequently coexist.
Observation:
- A 66-year-old woman with chronic thyroiditis experienced anorexia and fatigue, initially attributed to hypothyroidism.
- Following an increase in levothyroxine sodium dosage, she developed acute pseudogout.
- Sjögren's syndrome emerged during the course of treatment.
Findings:
- Pseudogout is a known complication of thyroid hormone replacement therapy.
- Colchicine effectively treated the pseudogout attack, unlike diclofenac sodium.
- This case presents a novel association between levothyroxine therapy, pseudogout, and Sjögren's syndrome.
Implications:
- Physicians should consider pseudogout in patients with thyroiditis on levothyroxine therapy presenting with joint pain.
- The potential link between thyroid replacement, pseudogout, and Sjögren's syndrome warrants further investigation.
- This case expands the understanding of potential adverse effects associated with thyroid hormone replacement.