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Related Experiment Videos

Leiomyosarcoma presenting as a mandibular gingival swelling: a case report.

P R Goldschmidt1, J D Goldschmidt, S E Lieblich

  • 1School of Dental Medicine, University of Connecticut, Farmington, USA.

Journal of Periodontology
|March 3, 1999
PubMed
Summary

A rare low-grade leiomyosarcoma of the mandible, initially mistaken for a dental issue, was successfully treated. This case highlights the importance of considering rare tumors in persistent jaw swellings.

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Area of Science:

  • Oral pathology
  • Surgical oncology
  • Mesenchymal neoplasms

Background:

  • Leiomyosarcoma, a malignant tumor of smooth muscle, rarely occurs in the mandible.
  • Primary mandibular tumors are uncommon, and leiomyosarcoma is exceptionally rare in this location.

Observation:

  • A young woman presented with a painful gingival swelling mimicking a periodontal infection.
  • Initial treatment with curettage, debridement, and antibiotics was unsuccessful.
  • Biopsy revealed a malignant mesenchymal neoplasm with smooth muscle actin (SMA) and vimentin expression.

Findings:

  • The diagnosis of primary low-grade leiomyosarcoma of the mandible was confirmed via immunohistochemistry.
  • Surgical management involved en bloc resection of the affected mandibular bone and soft tissue.

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  • Over 10 years of follow-up showed no recurrence or metastasis.

    • Implications:

    • This case underscores the diagnostic challenge of rare mandibular neoplasms presenting as common conditions.
    • Successful surgical resection offers a favorable prognosis for low-grade mandibular leiomyosarcoma.
    • A potential association between oral contraceptives and smooth muscle tumors warrants further investigation.