In vivo suppression of prostaglandin biosynthesis by non-steroidal anti-inflammatory agents

In vivo effects of orally administered inhibitors on prostaglandin and F levels were determined in seven organs of the rat. Ibuprofen showed suppression in most tissues three hours after dosing with a return to control values by twenty-four hours. Flurbiprofen and indomethacin showed potent suppression at both three and twenty-four hours after dosing. 3-Acetonitrile, 4,5-bis(p-methoxyphenyl)-2-phenyl-pyrrole showed moderate suppression only in the stomach and duodenum at three hours after dosing with a return to control values by twenty-four hours. Acetaminophen incorporated as a control showed statistically significant suppression only in the liver after twenty-four hours.