[Conditions affecting the renal excretion of manganese by humans (author's transl)]

The renal excretion of manganese is investigated for different urine flow rates in adults of both sexes with normal and disturbed kidney function. Mn is determined by emission spectral analysis. During antidiuresis with a mean urine flow rate of 0,97 +/- 0,66 ml/min (SD) the average excretion of Mn is 11,4 +/- 19,4 ng/min for 1,73 m2 body surface area. With an indifferent urine flow (4,43 +/- 2,11 ml/min) the average Mn excretion is 13,5 +/- 19,3 ng/min. For this type of diuresis Mn excretion and urine flow rate are slightly positively correlated. A further increase in urinary excretion of Mn is observed during osmotic diuresis. In this case 160,6 +/- 180,5 ng Mn/min are eliminated for an urine production of 22,2 +/- 6,8 ml/min. The difference of the mean excretion values is highly significant (P less than 0,01) between indifferent urine flow and osmotic diuresis, insignificant between antidiuresis and indifferent urine flow, and significant (P less than 0,01) between antidiuresis and osmotic diuresis. Down to a clearance value for inulin of less than 30 ml/min and for PAH of less than 200 ml/min and 1,73 m2 body surface area, the Mn excretion is largely independent of the renal hemodynamics.