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[Cad antigen in the French population]
Revue Francaise De Transfusion Et Immuno-Hematologie
|September 1, 1976
Summary
The Cad blood group antigen was identified in 0.07% of French blood donors. Cad red cells exhibited variable antigen strength and polyagglutinability, with distinct anti-Cad and anti-Sda specificities.
Area of Science:
- Immunology
- Genetics
- Hematology
Context:
- The Cad blood group system is a rare human blood group.
- Previous research on Cad phenotypes in the French population was limited.
- Blood transfusion centers in Mulhouse, Nancy, Paris, and Versailles participated in the study.
Purpose:
- To investigate the prevalence and characteristics of Cad phenotypes in the French population.
- To analyze the inheritance patterns and genetic independence of the Cad system.
- To characterize the serological properties of Cad red cells and antibodies.
Summary:
- A study of 78,528 French blood donors revealed 56 individuals with the Cad antigen (0.07% frequency).
- Cad antigen frequency varied across transfusion centers, potentially due to lectin extract preparation.
- Family studies demonstrated Cad system independence from other blood group systems (Auberger, Gc, Hp, C'3, PGM, Pac, ADA).
- Erythrocyte Cad strength showed high variability, even within families.
- Cad samples were often polyagglutinable.
- Adult sera contained anti-Cad1 antibodies, except in Cad1 individuals.
- Anti-Cad and anti-Sda specificities were distinct, confirmed by absorption and inhibition tests.
- Dolichos biflorus lectin did not show separable anti-A1 and anti-Cad agglutinins.
Impact:
- This study provides crucial data on the prevalence and serological characteristics of the Cad blood group in the French population.
- Findings contribute to understanding blood group genetics and transfusion compatibility.
- Highlights the importance of careful reagent preparation and advanced techniques in blood group antigen detection.