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[Granulocyte transfusions. Technical data, granulocyte function and results].

R Medenica, P Maurice, A Cruchaud

    Schweizerische Medizinische Wochenschrift
    |October 2, 1976
    PubMed
    Summary
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    Repetitive filtration leukopheresis offers a new method for granulocyte transfusions in neutropenic patients. This technique shows favorable results with improved cell tolerance and function, avoiding common side effects.

    Area of Science:

    • Hematology
    • Transfusion Medicine
    • Cellular Therapy

    Context:

    • Neutropenia (<300/mm3) poses a significant risk of infection.
    • Antibiotic-resistant infections require alternative therapeutic strategies.
    • Granulocyte transfusion therapy is used for severe neutropenia and infection.

    Purpose:

    • To describe a novel repetitive filtration leukopheresis method for granulocyte collection.
    • To evaluate the efficacy and safety of this new leukapheresis technique.
    • To assess the functional integrity and tolerance of collected granulocytes.

    Summary:

    • A cohort of 23 neutropenic patients received 91 granulocyte transfusions using repetitive filtration leukopheresis.
    • Favorable clinical outcomes were observed in 18 patients with antibiotic-resistant infections.

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  • The procedure demonstrated remarkable tolerance, with an absence of common transfusion side effects like chills, rash, fever, or dyspnea.

    • Impact:

    • The novel collection method preserves granulocyte function (phagocytosis, bacteriolysis).
    • Elution at pH 7.4 and omission of centrifugation contribute to enhanced cell viability and reduced adverse events.
    • This technique offers a promising alternative for granulocyte transfusion therapy in immunocompromised patients.