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[Benign thyroid nodules in the elderly. Medical treatment]
I Cramarossa1, A A Caruso, L Morena
1Cattedra di Geriatria III, Università degli Studi di Roma La Sapienza.
Minerva Endocrinologica
|March 4, 1999
Summary
L-thyroxine treatment for benign thyroid nodules in the elderly showed limited efficacy, with most patients remaining stable. This medical therapy is recommended due to its safety and cost-effectiveness in managing these common thyroid conditions.
Area of Science:
- Endocrinology
- Geriatrics
Background:
- Benign thyroid nodules are common, particularly in older adults, but treatment remains debated.
- Reported efficacy of L-thyroxine for reducing nodule size or number varies significantly (9-68%).
Purpose of the Study:
- To evaluate the therapeutic effectiveness of L-thyroxine in elderly patients with benign thyroid nodules.
Main Methods:
- Retrospective study of 105 elderly patients (mean age 68) with thyroid nodules.
- Exclusion of confounding diseases, comprehensive hormonal assays (TSH, thyroid hormones, antibodies), ultrasonography, scintigraphy, and fine-needle aspiration.
- Treatment with L-thyroxine (75-150 mcg/day) with follow-up at 6, 12, and 24 months.
Main Results:
- Approximately 85% of patients showed no change in their condition.
- Fewer than 10% experienced improvement.
- A small number of patients exhibited symptom deterioration.
Conclusions:
- L-thyroxine therapy is considered a primary treatment option for benign thyroid nodules in the elderly.
- Its advantages include ease of administration, low cost, and minimal side effects.