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Slowed cognitive processing and high workload in Parkinson's disease.

C Robertson1, J Empson

  • 1Department of Psychology, University of Lincolnshire and Humberside, Hull, UK. crobertson@humber.ac.uk

Journal of the Neurological Sciences
|March 4, 1999
PubMed
Summary

Cognitive slowing in Parkinson's disease (PD) is linked to high cognitive load tasks. Event-related potentials (ERPs) revealed reduced P300 in PD patients, indicating slower stimulus evaluation, not response selection.

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neurology

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder.
  • Cognitive slowing is a common symptom in PD.
  • The impact of cognitive load on PD-related cognitive slowing requires further investigation.

Purpose of the Study:

  • To investigate cognitive slowing in Parkinson's disease using a high cognitive load task.
  • To differentiate between stimulus evaluation and response selection deficits in PD.

Main Methods:

  • A workload design with progressively increasing task difficulty was employed.
  • Measures included Reaction Time (RT) and Event-Related Potentials (ERPs).
  • Participants comprised a group of Parkinson's patients and a control group.

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Main Results:

  • Both RT and ERP waveforms increased with task difficulty in all participants.
  • No significant differences in RT were observed between PD patients and controls.
  • PD patients exhibited a significantly reduced P300 component in their ERPs.

Conclusions:

  • The findings suggest cognitive slowing in Parkinson's disease, specifically during the stimulus evaluation stage.
  • Response selection processes do not appear to be affected by cognitive load in PD.
  • Reduced neural activation may underlie cognitive slowing in PD.