Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interferons and cerebral palsy.

J K Grether1, K B Nelson, J M Dambrosia

  • 1California Birth Defects Monitoring Program, California Department of Health Services, Emeryville, California, USA.

The Journal of Pediatrics
|March 4, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Soybean genotype amino acid selection and processing method effects on broiler performance.

Poultry science·2026
Same author

Placental contribution to neonatal encephalopathy.

Seminars in fetal & neonatal medicine·2021
Same author

Neonatal encephalopathy: Focus on epidemiology and underexplored aspects of etiology.

Seminars in fetal & neonatal medicine·2021
Same author

Innervation of the placenta and uterus: competition between cytotrophoblasts and nerves?

Placenta·2013
Same author

The placenta and neurologic and psychiatric outcomes in the child: study design matters.

Placenta·2011
Same author

Expression of ia antigens by murine keratinizing epithelial langerhans cells.

Immunogenetics·2011
Same journal

Respiratory Syncytial Virus Immunization Disparities in Mothers and Infants at the Birth Hospitalization: A Cross-Sectional Study.

The Journal of pediatrics·2026
Same journal

Blood-Based Biomarkers Predict Cerebral Palsy and Cognitive Delay in Hypoxic-Ischemic Encephalopathy: A Secondary Analysis of the HEAL Randomized Controlled Trial.

The Journal of pediatrics·2026
Same journal

Does Mild Head Injury in Childhood Affect Later School Performance? A Sibling Comparison Cohort Study.

The Journal of pediatrics·2026
Same journal

Risk Factors for Mortality and Age at Discharge in Preterm Infants with Congenital Heart Disease.

The Journal of pediatrics·2026
Same journal

To Cool or Not to Cool in Low- and Middle-Income Countries:? A Call for Resources, Training and Shared Knowledge.

The Journal of pediatrics·2026
Same journal

Responsible Research Practices in Pediatrics: How Reporting Guidelines Can Be Used to Improve Trial Design and Conduct.

The Journal of pediatrics·2026
See all related articles

High neonatal interferons (IFNs) were linked to spastic cerebral palsy (CP) and inflammation markers. Lower IFNs in CP infants correlated with different inflammatory profiles and spastic hemiplegia, suggesting distinct CP subtypes.

Area of Science:

  • Neonatal immunology
  • Neuroscience
  • Biochemistry

Background:

  • Cerebral palsy (CP) is a complex neurological disorder.
  • The role of neonatal immune factors in CP pathogenesis requires further investigation.
  • Interferons (IFNs) are key immune signaling molecules with diverse functions.

Purpose of the Study:

  • To investigate the association between neonatal interferon (IFN) levels and spastic cerebral palsy (CP).
  • To explore correlations between neonatal IFNs and other measured biochemical substances in infants with CP.
  • To differentiate CP subtypes based on neonatal IFN profiles.

Main Methods:

  • Archived neonatal blood samples from 31 children with CP and 65 controls were analyzed.
  • Immunoaffinity chromatography with laser-enhanced fluorescence and chemiluminescence detection was employed.

Related Experiment Videos

  • Quantification of interferons (IFNs) and various inflammatory markers, cytokines, and coagulation factors was performed.

    • Main Results:

    • Elevated neonatal IFN-alpha, beta, and gamma concentrations were observed in 14 of 31 children with spastic CP.
    • These 14 children also showed altered levels of interleukins, TNF-alpha, chemokines, and other factors.
    • Children with CP and normal IFN levels exhibited different inflammatory profiles and coagulation factor concentrations, with some cases linked to spastic hemiplegia.

    Conclusions:

    • Neonatal interferons exceeding control concentrations are associated with inflammation and spastic diplegia in CP.
    • In CP infants, IFNs within the control range correlate with near-control inflammatory markers and spastic hemiplegia.
    • These findings suggest distinct immunological pathways contributing to different CP subtypes.