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Fixed drug eruptions in children.

J G Morelli1, Y K Tay, M Rogers

  • 1Department of Dermatology, University of Colorado School of Medicine, Denver, Colorado 80262, USA.

The Journal of Pediatrics
|March 4, 1999
PubMed
Summary
This summary is machine-generated.

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Fixed drug eruptions (FDE) in children were analyzed retrospectively. Trimethoprim-sulfamethoxazole was identified as the most frequent cause of FDE in pediatric patients.

Area of Science:

  • Pediatric Dermatology
  • Pharmacovigilance

Background:

  • Fixed drug eruptions (FDE) are a specific type of adverse drug reaction.
  • Identifying causative agents and common presentations in pediatric populations is crucial for clinical management.

Purpose of the Study:

  • To identify the most common drugs causing fixed drug eruptions in children.
  • To describe the typical anatomical locations of fixed drug eruptions in pediatric patients.

Main Methods:

  • A 5-year retrospective analysis was conducted.
  • Data from 35 children diagnosed with fixed drug eruptions were evaluated.

Main Results:

  • The combination drug trimethoprim-sulfamethoxazole was the most common etiology of FDE.
  • Anatomic distribution patterns were documented.

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Conclusions:

  • Trimethoprim-sulfamethoxazole is a significant cause of FDE in children.
  • Understanding FDE triggers and locations aids in diagnosis and prevention in pediatric care.