Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ribosomal RNA expression in the developing rat olfactory bulb.

B K Fiske1, P C Brunjes

  • 1Neuroscience Program and Department of Psychology, University of Virginia, Charlottesville, VA 22903, USA.

Brain Research. Developmental Brain Research
|March 5, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Myelination of the developing lateral olfactory tract and anterior commissure.

The Journal of comparative neurology·2018
Same author

Neonatal focal denervation of the rat olfactory bulb alters cell structure and survival: a Golgi, Nissl and confocal study.

Brain research. Developmental brain research·2003
Same author

Blue-white selection step enhances the yield of SAGE concatemers.

BioTechniques·2002
Same author

Neurogenesis in the olfactory bulb of adult zebrafish.

Neuroscience·2001
Same author

NMDA receptor regulation of cell death in the rat olfactory bulb.

Journal of neurobiology·2001
Same author

Activity modulates neuronal proliferation in the developing olfactory epithelium.

Brain research. Developmental brain research·2001
Same journal

Postnatal development of GFAP, connexin43 and connexin30 in cat visual cortex.

Brain research. Developmental brain research·2005
Same journal

Expression of gamma-aminobutyric acid B receptor subunits in hypothalamus of male and female developing rats.

Brain research. Developmental brain research·2005
Same journal

Retinal neurospheres prepared as tissue for transplantation.

Brain research. Developmental brain research·2005
Same journal

Effects of prenatal stress on anxiety and social interactions in adult rats.

Brain research. Developmental brain research·2005
Same journal

Disruption of cerebellar granule cell development in the Pax6 mutant, Sey mouse.

Brain research. Developmental brain research·2005
Same journal

Cytoskeletal, synaptic, and nuclear protein changes associated with rat interface organotypic hippocampal slice culture development.

Brain research. Developmental brain research·2005
See all related articles

Ribosome development in the rat olfactory bulb shows significant postnatal changes. Naris occlusion had minimal impact on ribosome expression, indicating intrinsic growth patterns.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Developmental Biology

Background:

  • The rat olfactory bulb experiences rapid postnatal growth, necessitating continuous protein synthesis.
  • Ribosomes are crucial for protein synthesis and their development is key to understanding cellular growth.

Purpose of the Study:

  • To investigate the developmental trajectory of ribosomes in the rat olfactory bulb.
  • To explore the influence of afferent activity on ribosome expression patterns.

Main Methods:

  • Utilized an antibody specific to ribosomal RNA (Y10b) to examine ribosome development.
  • Assessed total RNA production via 3H-uridine incorporation.
  • Investigated the effects of naris occlusion on postnatal day 1 (P1).

Related Experiment Videos

Main Results:

  • Ribosome expression (Y10b immunoreactivity) expanded from mitral cells at P2 to all layers by P10, with increased density by P30.
  • Naris occlusion did not alter Y10b patterns at early time points, but showed a decrease in labeled profiles in the external plexiform layer by P30.
  • No significant changes in 3H-uridine incorporation were observed due to naris occlusion.

Conclusions:

  • Ribosome expression in the rat olfactory bulb undergoes dynamic postnatal changes that correlate with overall bulb growth.
  • Afferent activity, modulated by naris closure, appears to have a limited impact on early ribosome development in this region.