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Related Experiment Videos

Long term depression is expressed during postnatal development in rat visual cortex: a role for visual experience.

E Sermasi1, D Tropea, L Domenici

  • 1International School for Advanced Studies (SISSA), Neuroscience Program, Via Beirut 2-4, 34014, Trieste, Italy.

Brain Research. Developmental Brain Research
|March 5, 1999
PubMed
Summary

Long-term depression (LTD) is present in the developing visual cortex at all ages studied. However, visual experience is crucial, as dark rearing reduces LTD expression in young rats.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Visual System Plasticity

Background:

  • Synaptic plasticity, including Long-Term Depression (LTD) and Long-Term Potentiation (LTP), is crucial for brain function.
  • While LTP is not inducible in adult mammals, LTD can be elicited, but its developmental trajectory remains unclear.

Purpose of the Study:

  • To investigate the expression of LTD during postnatal development in the rat visual cortex.
  • To determine if visual experience modulates LTD during this critical developmental period.

Main Methods:

  • Electrophysiological recordings of extracellular field potentials in rat primary visual cortex slices.
  • Stimulation of white matter using low-frequency stimulation at postnatal days 17, 23, and 30-35.
  • Assessment of LTD induction and amplitude.

Related Experiment Videos

  • Comparison between normally reared, dark-reared, and light-deprived rats.

    • Main Results:

    • LTD was expressed at all investigated postnatal ages (P17, P23, P30-35) with no significant age-related differences.
    • Dark rearing from birth to P23 significantly reduced LTD amplitude.
    • Light deprivation from P17 to P30 did not affect LTD expression compared to controls.

    Conclusions:

    • The developmental expression of LTD in the rat visual cortex is not strictly tied to the primary maturation period.
    • Early visual experience, specifically light imprinting, is essential for the normal expression of LTD during postnatal development.