Expression of brain-2 in the developing olfactory bulb
Related Experiment Video
Updated: Oct 24, 2026

Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes
Published on: June 5, 2017
K Hagino-Yamagishi1, R Minamikawa-Tachino, M Ichikawa
1Department of Ultrastructural Research, Tokyo Metropolitan Institute of Medical Science, Honkomagome 3-18-22, Bunkyo-ku, Tokyo 113, Japan. yamagishi@rinshoken.or.jp
Abstract:
The expression of Brain-2, a POU domain transcription factor, was examined in the developing olfactory bulb. Brain-2 was expressed mainly in the output neurons, mitral cell and tufted cells in the main olfactory bulb (MOB), and mitral/tufted cells (MT cells) in the accessory olfactory bulb (AOB). It was not expressed in granular cells in either the MOB or the AOB. Our results suggest that Brain-2 was specifically expressed in output neurons but not in interneurons in the developing olfactory bulb. Brain-2 may play a role in the development of these output neurons.
Related Concept Videos
Physiology of Smell and Olfactory Pathway
The olfactory...
Olfaction
The olfactory receptors are embedded in the cilia of the...
Olfactory Receptors: Location and Structure

