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Lupus anticoagulant syndrome: case report
1Department of Haematology and Blood Transfusion, College of Health Sciences, University of Nairobi.
East African Medical Journal
|March 5, 1999
Summary
This case study highlights a young woman diagnosed with lupus anticoagulant syndrome, identified through coagulation tests and antibody screening. Early detection and treatment are crucial for managing this condition and preventing complications like deep vein thrombosis.
Area of Science:
- Hematology
- Immunology
Background:
- Deep vein thrombosis (DVT) and recurrent pregnancy loss can be associated with coagulation disorders.
- Lupus anticoagulant (LA) is an autoantibody that can interfere with blood clotting.
Observation:
- A 27-year-old female presented with DVT, prolonged activated partial thromboplastin time (aPTT), and an elevated prothrombin time (PT) INR.
- Coagulation studies revealed a lupus anticoagulant, positive VDRL test, and elevated anticardiolipin antibodies (IgG).
Findings:
- The patient was diagnosed with lupus anticoagulant syndrome, a condition characterized by the presence of LA and associated clinical manifestations.
- Diagnostic workup confirmed the presence of a coagulation inhibitor affecting both aPTT and PT.
Implications:
- This case underscores the importance of investigating coagulation abnormalities in patients with unexplained thrombosis and pregnancy loss.
- Prompt diagnosis and management of lupus anticoagulant syndrome with anticoagulants and antiplatelet agents can improve patient outcomes.