Related Experiment Videos
Dopamine D3 receptor polymorphism is not associated with the polycystic ovary syndrome
M Kahsar-Miller1, L R Boots, R Azziz
1Department of Obstetrics and Gynecology, The University of Alabama at Birmingham, 35233-7333, USA.
Objective:
To determine if a polymorphism of the dopamine D3 receptor gene (2 allele), which has been reported previously to be associated with polycystic ovary syndrome (PCOS) in a population of United States Hispanic women, is associated with the disorder in the southeastern United States.
Design:
Prospective case-control study.
Setting:
University reproductive endocrinology laboratory and outpatient clinic.
Patient(S):
Consecutive patients of non-Hispanic white race diagnosed with PCOS (n = 152) and healthy controls (n = 96).
Intervention(S):
None.
Main Outcome Measure(S):
Patient and control dopamine D3 receptor genotypes, with the 1 allele representing the wild type and the 2 allele denoting a highly prevalent polymorphism.
Result(S):
No difference was noted in the distribution of the three dopamine D3 receptor genotypes (i.e., 1:1, 1:2, and 2:2) among PCOS patients as compared with controls. Furthermore, in contrast to a previous report, the 2:2 genotype was not more prevalent among PCOS patients than among controls.
Conclusion(S):
Our population of non-Hispanic white women from the southeastern United States did not demonstrate an association between a dopamine D3 receptor polymorphism and PCOS.