Related Experiment Videos
Increased angiotensin-converting enzyme activity in a patient with severe ovarian hyperstimulation syndrome
1Division of Reproductive Endocrinology, Center for Human Reproduction and University of Illinois School of Medicine, Chicago 60610, USA. cfhr@ais.net
Objective:
To assess plasma angiotensin-converting enzyme (ACE) activity in a patient with severe ovarian hyperstimulation syndrome (OHSS).
Design:
Case report.
Setting:
Private, university-affiliated infertility practice.
Patient(S):
A 35-year-old woman with OHSS.
Intervention(S):
Clomiphene citrate induction of ovulation.
Main Outcome Measure(S):
Plasma ACE activity.
Result(S):
The patient had a brain stem infarction as a result of thrombosis caused by severe OHSS. Plasma ACE activity was significantly elevated and persisted long after resolution of the OHSS.
Conclusion(S):
Elevated ACE activity appears to have been associated with the development of OHSS in this patient. Further study of the ovarian renin-angiotensin system in the development of OHSS is warranted.