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Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jul 17, 2026

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

Mitochondrial diseases in man and mouse.

¹Center for Molecular Medicine, Emory University, 1462 Clifton Road, Suite 420, Atlanta, GA 30322, USA. dwallace@gmm.gen.emory.edu

Science (New York, N.Y.)

|March 5, 1999

Summary

Mitochondrial defects are linked to aging, cancer, and degenerative diseases. Research using mouse models investigates the complex genetic and pathological mechanisms underlying these conditions.

Area of Science:

Biochemistry
Genetics
Cell Biology

Background:

Mitochondrial defects are increasingly implicated in aging, cancer, and degenerative diseases.
Mitochondrial genetics involves complex interactions between mitochondrial and nuclear genomes.
The pathophysiology of mitochondrial diseases remains poorly understood.

Purpose of the Study:

To investigate the complex mechanisms of mitochondrial pathology.
To explore the role of mitochondrial oxidative phosphorylation in disease.
To study the interrelationship of mitochondrial functions in disease pathogenesis.

Main Methods:

Analysis of patient studies on mitochondrial genetics.
Utilizing mouse models to study mitochondrial disease.

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Investigating cellular energy production, reactive oxygen species generation, and apoptosis.

Main Results:

Mitochondrial defects play a significant role in various diseases.
Genetic interplay between mitochondrial and nuclear genomes is crucial.
Mouse models provide insights into mitochondrial disease mechanisms.

Conclusions:

Mitochondrial function is critical for cellular health.
Further research in mouse models is essential for understanding mitochondrial diseases.
Targeting mitochondrial pathways may offer therapeutic strategies.