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Brain-derived neurotrophic factor prevents low-frequency inputs from inducing long-term depression in the developing

S Kinoshita1, H Yasuda, N Taniguchi

  • 1Department of Neurophysiology, Biomedical Research Center, Osaka University Medical School, Suita, 565-0871 Japan.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|March 5, 1999
PubMed
Summary

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Brain-derived neurotrophic factor (BDNF) normally prevents synaptic depression. Blocking BDNF allows low-frequency stimulation to induce long-term depression (LTD) in the visual cortex, revealing its role in synaptic plasticity.

Area of Science:

  • Neuroscience
  • Synaptic Plasticity

Background:

  • Brain-derived neurotrophic factor (BDNF) enhances synaptic transmission and long-term potentiation (LTP).
  • A potential role for BDNF in regulating long-term depression (LTD) remains unexplored.

Purpose of the Study:

  • To investigate if BDNF shortage or blockade induces LTD.
  • To elucidate the mechanisms underlying BDNF's influence on LTD in the visual cortex.

Main Methods:

  • Whole-cell voltage-clamp recordings from rat visual cortical slices.
  • Low-frequency stimulation (LFS) with varying postsynaptic depolarization.
  • Application of exogenous BDNF, anti-BDNF antibody, and BDNF receptor inhibitors.

Main Results:

  • LTD was induced by LFS paired with postsynaptic depolarization but not by LFS alone.

Related Experiment Videos

  • Exogenous BDNF blocked LTD induction, suggesting presynaptic involvement.
  • Suppression of endogenous BDNF activity facilitated LTD induction by LFS without depolarization.

    • Conclusions:

    • Endogenous BDNF likely prevents LTD induction by low-frequency inputs in the developing visual cortex.
    • BDNF plays a critical role in regulating synaptic plasticity by inhibiting LTD.