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Related Experiment Videos

Fimbriae-mediated host-pathogen cross-talk.

S N Abraham1, A B Jonsson, S Normark

  • 1Department of Pathology and Microbiology, Duke University Medical Center, Box 3712, Durham, NC 27710, USA. Abrah006@mc.duke.edu

Current Opinion in Microbiology
|March 6, 1999
PubMed
Summary
This summary is machine-generated.

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Bacterial fimbriae, like those from uropathogenic Escherichia coli, dynamically bind host cell receptors. This interaction involves signaling to both bacteria and host cells, revealing novel virulence mechanisms.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Immunology

Background:

  • Uropathogenic Escherichia coli and pathogenic Neisseria species utilize fimbriae for host cell adhesion.
  • Fimbrial adhesin-receptor interactions are crucial for bacterial pathogenesis at mucosal surfaces.

Purpose of the Study:

  • To investigate the dynamic nature of fimbrial adhesin-host cell receptor coupling.
  • To elucidate novel signaling mechanisms involved in bacterial adhesion and virulence.

Main Methods:

  • Analysis of fimbrial adhesin-receptor interactions.
  • Investigation of host cell and bacterial signaling pathways during adhesion.

Main Results:

  • The coupling of fimbrial adhesins to host receptors is a dynamic process.

Related Experiment Videos

  • Specific signaling occurs in both bacteria and host cells upon fimbrial binding.
  • Novel mechanisms of virulence promotion at mucosal and deeper tissues were identified.

    • Conclusions:

    • Bacterial fimbriae employ sophisticated, dynamic mechanisms for host cell engagement.
    • Understanding these interactions provides insights into bacterial pathogenesis and potential therapeutic targets.