Signal transduction in bacteria: molecular mechanisms of stimulus-response coupling
Related Experiment Video
Updated: Oct 24, 2026

DNA-affinity-purified Chip (DAP-chip) Method to Determine Gene Targets for Bacterial Two component Regulatory Systems
Published on: July 21, 2014
1Center for Advanced Biotechnology and Medicine, Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, 679 HoesLane, Piscataway, NJ 08854-5638, USA. goudreau@mbcl.rutgers.edu
Abstract:
In bacteria, adaptive responses to changing environmental conditions are mediated by signal transduction systems that involve modular protein domains. Despite great diversity in the integration of domains into different systems, studies of individual components have revealed molecular strategies that are widely applicable. Studies of receptors have advanced our understanding of how information is transmitted across membranes, the determination of three-dimensional structures of domains of histidine protein kinase domains and response regulator proteins has begun to reveal the molecular basis of signaling via two-component phosphoryltransfer pathways, and the description of 'eukaryotic-like' protein domains involved in bacterial signaling has emphasized the universality of intracellular signaling mechanisms.
More Related Videos
Related Concept Videos
Bacterial Signaling
Global Regulatory Systems
Other Stress Responses in Bacteria
Gene Regulation in Microbial Communities: Quorum Sensing
Coordination of Gene Expression Processes in Bacteria
Signal Transduction: Overview
Typically, signal transduction involves three...

