Initiation of bacterial development

The discovery of a mitotic apparatus in bacteria has led to significant recent progress being made in understanding the regulatory connections between the cell cycle, chromosome segregation and the onset of developmental processes in sporulation. The control of developmental transcription by antagonism between protein kinase and protein phosphatase reached a new level of complexity with the discovery of peptide inhibitors of protein phosphatases that cycle between the interior and exterior cell surface as information messengers. New mechanisms of developmental regulation are being uncovered in a variety of microbial systems.