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Related Experiment Videos

Herpes simplex virus latency and the immune response.

M Daheshia1, L T Feldman, B T Rouse

  • 1Department of Microbiology, The University of Tennessee, Knoxville, TN 37996-0845, USA.

Current Opinion in Microbiology
|March 6, 1999
PubMed
Summary

Herpes simplex virus establishes lifelong latency in nerve cells, periodically reactivating. This study investigates the molecular mechanisms of viral latency, maintenance, and reactivation, alongside the immune system's role.

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Area of Science:

  • Virology
  • Neuroscience
  • Immunology

Background:

  • Herpes simplex virus (HSV) establishes lifelong latency in the nervous system after initial infection.
  • Periodic recurrences of lytic replication are characteristic of HSV infections.
  • Understanding the molecular basis of HSV latency and reactivation is crucial for managing recurrent disease.

Purpose of the Study:

  • To investigate the molecular events governing HSV entry into latency.
  • To elucidate the mechanisms maintaining HSV latency.
  • To understand the processes occurring during HSV reactivation and the role of the immune response.

Main Methods:

  • Molecular biology techniques to study viral gene expression during latency and reactivation.
  • In vivo and in vitro models of HSV infection and latency.

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  • Immunological assays to assess the host immune response to HSV.

    • Main Results:

    • Identification of key viral and host factors involved in establishing and maintaining HSV latency.
    • Characterization of molecular triggers for HSV reactivation.
    • Demonstration of the immune system's critical role in controlling HSV infection and reactivation.

    Conclusions:

    • HSV latency is a complex process involving intricate molecular interactions between the virus and the host nervous system.
    • The immune response plays a vital role in controlling HSV, influencing latency, and clearing reactivated virus.
    • Further research into these mechanisms could lead to novel therapeutic strategies against HSV infections.