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Comparative mycobacterial genomics.

S T Cole1

  • 1Unité de Génétique Moléculaire Bactérienne Institut Pasteur 28 rue du Docteur Roux 75724 Paris Cedex 15 France. stcole@pasteur.fr.

Current Opinion in Microbiology
|March 6, 1999
PubMed
Summary
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Genomics reveals Mycobacterium tuberculosis and Mycobacterium leprae share biochemical and pathogenic information. Mycobacterium leprae’s genome shows shrinkage and gene inactivation, explaining its slow growth.

Area of Science:

  • Microbiology and Genomics

Background:

  • Genomics offers insights into the biochemistry, physiology, and pathogenesis of Mycobacterium tuberculosis and Mycobacterium leprae.
  • Comparative genomics between these two species provides valuable, mutually beneficial information.

Purpose of the Study:

  • To compare the genome sequences of Mycobacterium tuberculosis and Mycobacterium leprae.
  • To understand the genomic basis for the slow growth of Mycobacterium leprae.

Main Methods:

  • Genome sequence comparison between Mycobacterium tuberculosis and Mycobacterium leprae.

Main Results:

  • The Mycobacterium leprae genome exhibits significant shrinkage compared to Mycobacterium tuberculosis.
  • Large-scale gene inactivation is evident in the Mycobacterium leprae genome.

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Conclusions:

  • Genome shrinkage and gene inactivation in Mycobacterium leprae likely contribute to its exceptionally slow growth rate.
  • Comparative genomics is a powerful tool for understanding mycobacterial evolution and biology.