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Related Experiment Videos

Mechanism for the posture-specific plasma volume increase after a single intense exercise protocol.

K Nagashima1, G W Mack, A Haskell

  • 1The John B. Pierce Laboratory, Departments of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06519, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|March 6, 1999
PubMed
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Exercise posture affects fluid balance. Upright exercise leads to plasma volume expansion and increased albumin, unlike supine exercise, suggesting posture influences exercise-induced hypervolemia mechanisms.

Area of Science:

  • Physiology
  • Exercise Science
  • Fluid Balance

Background:

  • Exercise-induced hypervolemia is a complex physiological response.
  • The role of body posture in regulating post-exercise fluid shifts is not fully understood.

Purpose of the Study:

  • To investigate whether exercise-induced hypervolemia is dependent on body posture.
  • To examine the influence of upright versus supine exercise on plasma volume and albumin content.

Main Methods:

  • Seven healthy subjects underwent intense exercise (85% peak VO2) in either upright or supine positions.
  • Plasma volume, plasma albumin, and renal function were measured for 22 hours post-exercise.
  • Subjects maintained their respective postures for 5 hours during recovery.
Keywords:
NASA Discipline CardiopulmonaryNon-NASA Center

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Main Results:

  • Plasma volume initially decreased during exercise but returned to baseline by 5 hours post-exercise in both postures.
  • By 22 hours, upright exercise induced a significant plasma volume expansion (2.4 ml/kg), while supine exercise resulted in a decrease (-2.1 ml/kg).
  • Upright exercise increased plasma albumin content, correlating with plasma volume expansion, whereas supine exercise did not.

Conclusions:

  • Increased plasma albumin content appears to contribute to the acute phase of exercise-induced hypervolemia.
  • Body posture significantly alters the post-exercise distribution of albumin and subsequent plasma volume changes.
  • The underlying mechanisms by which posture influences these fluid shifts remain to be elucidated.