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Published on: October 2, 2014
CT angiography and Doppler sonography for emergency assessment in acute basilar artery ischemia
T Brandt1, M Knauth, S Wildermuth
1Department of Neurology, University of Heidelberg, Germany. tobiasvbrandt@ukl.uni-heidelberg.de
Insights
CT angiography (CTA) is superior to Doppler sonography (DS) for diagnosing basilar artery (BA) occlusion in acute cerebral ischemia. CTA offers better feasibility and conclusiveness, especially for distal occlusions, aiding treatment decisions.
Area of Science:
- Neurology
- Vascular Imaging
- Medical Diagnostics
Background:
- Acute basilar artery (BA) ischemia presents a diagnostic challenge.
- Noninvasive vascular assessment tools like Doppler sonography (DS) and CT angiography (CTA) are crucial.
- The diagnostic utility of CTA in acute BA ischemia remained unstudied.
Purpose of the Study:
- To evaluate the diagnostic performance of CTA compared to DS for acute basilar artery occlusion.
- To assess the feasibility and conclusiveness of CTA in identifying BA patency and occlusion.
Main Methods:
- Prospective study of 19 patients with suspected acute BA occlusion.
- Utilized both Doppler sonography (DS) and CT angiography (CTA) for vascular assessment.
- Digital subtraction angiography (DSA) was performed in 6 patients for comparison.
Main Results:
- CTA was diagnostic in 18 of 19 patients, accurately identifying BA occlusion (complete/incomplete) or patency.
- DS was diagnostic in only 7 of 19 patients, with 9 inconclusive results and 2 false-negatives for distal occlusion.
- CTA provided detailed information on occlusion site, length, and collateral pathways, guiding thrombolysis in 5 patients.
Conclusions:
- CTA demonstrated superior feasibility and conclusiveness over DS for assessing BA patency in acute ischemia.
- CTA is particularly advantageous for diagnosing distal BA occlusions.
- Combined extracranial and transcranial DS remains useful for proximal BA occlusion diagnosis.
Background And Purpose:
Both Doppler sonography (DS) and spiral CT angiography (CTA) are noninvasive vascular assessment tools with a high potential for application in acute cerebral ischemia. The usefulness of CTA for vascular diagnosis in acute basilar artery (BA) ischemia has not yet been studied.
Methods:
We prospectively studied 19 patients (mean+/-SD age, 58+/-11 years) with clinically suspected acute BA occlusion by DS and CTA. Prior extracranial and transcranial DS was performed in all but 1 patient, with DS 4 hours after CTA. In 6 of 19 patients, we performed digital subtraction angiography.
Results:
CTA was diagnostic in all but 1 patient. CTA revealed complete BA occlusion in 9 patients and incomplete BA occlusion with some residual flow in 2 patients. A patent BA was shown in 7 patients. Because of severe BA calcification, CTA results were inconclusive in 1 patient. DS was diagnostic in only 7 of 19 patients, indicating certain BA occlusion in 3 patients and BA patency in 4 patients. In an additional 9 patients, the results of DS were inconclusive. DS was false-negative in 2 patients with distal BA occlusion shown by CTA and digital subtraction angiography. In 1 patient with DS performed after CTA, recanalization was demonstrated. In addition to the diagnosis or exclusion of BA occlusion, CTA provided information on the exact site and length of BA occlusion and collateral pathways. In our series, CTA results prompted indication for intra-arterial thrombolysis in 5 patients.
Conclusions:
CTA was superior to DS in the assessment of BA patency in patients with the syndrome of acute BA ischemia in terms of feasibility and conclusiveness, particularly in cases with distal BA occlusion. Our study confirmed the usefulness of combined extracranial and transcranial DS in the diagnosis and exclusion of proximal BA occlusion.
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