Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intercellular IgA dermatosis.

K C Ongenae1, L J Temmerman, F Vermander

  • 1Department of Dermatology, University Hospital, Gent, Belgium.

European Journal of Dermatology : EJD
|March 6, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recommendations for the use of etanercept in psoriasis: a European dermatology expert group consensus.

Journal of the European Academy of Dermatology and Venereology : JEADV·2006
Same author

Clinical and molecular abnormalities in lipoid proteinosis.

European journal of dermatology : EJD·2005
Same author

Effect of vitiligo on self-reported health-related quality of life.

The British journal of dermatology·2005
Same author

Quality of life and stigmatization profile in a cohort of vitiligo patients and effect of the use of camouflage.

Dermatology (Basel, Switzerland)·2005
Same author

Ciclosporin in psoriasis clinical practice: an international consensus statement.

The British journal of dermatology·2004
Same author

Topical class I corticosteroids in 10 patients with bullous pemphigoid: correlation of the outcome with the severity degree of the disease and review of the literature.

Journal of the European Academy of Dermatology and Venereology : JEADV·2004
Same journal

Erratum.

European journal of dermatology : EJD·2026
Same journal

sQUIZ your knowledge! A hidden flexural pattern revealed.

European journal of dermatology : EJD·2026
Same journal

sQuiz your knowledge! A new pigmented lesion on the back of a young woman.

European journal of dermatology : EJD·2026
Same journal

sQuiz your knowledge! Multiple yellowish papules in an adult.

European journal of dermatology : EJD·2026
Same journal

sQuiz your knowledge! When plaques turn into tumours.

European journal of dermatology : EJD·2026
Same journal

sQuiz your knowledge! A gradually progressive pigmented dermatosis.

European journal of dermatology : EJD·2026
See all related articles

Intercellular IgA dermatosis (IAD) is a spectrum of skin diseases involving IgA deposition. This review highlights its varied presentations, from pustular eruptions to pemphigus variants, and discusses diagnostic and therapeutic considerations.

Area of Science:

  • Immunodermatology
  • Dermatopathology

Background:

  • Intercellular IgA dermatosis (IAD) encompasses a range of vesiculobullous and vesiculopustular skin disorders.
  • These conditions are characterized by the deposition of immunoglobulin A (IgA) between epidermal cells.

Observation:

  • Clinical presentations of IAD vary widely, including pustular eruptions on the trunk and extremities, and features resembling pemphigus variants.
  • Histopathology often reveals polymorphonuclear cell infiltration and pustule/bulla formation within the epidermis, though some cases mimic classic pemphigus histologically.
  • Direct immunofluorescence typically shows intercellular IgA deposition, while indirect immunofluorescence may detect low levels of circulating antibodies.

Findings:

  • IAD is frequently associated with monoclonal IgA gammopathy.

Related Experiment Videos

  • Treatment with dapsone is effective in most cases.
  • The IgA antibodies in IAD can target known pemphigus antigens or novel antigens (105 kD, 115 kD, 120 kD).

    • Implications:

    • IAD represents a spectrum of disease, ranging from IgA pemphigus to intercellular IgA vesiculopustular dermatosis.
    • Understanding this heterogeneity is crucial for accurate diagnosis and management.
    • Further research into novel antigen targets may improve understanding and treatment strategies for IAD.