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Total synthesis of the naturally occurring antibiotic toyocamycin using new and improved synthetic procedures
1Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor 48109-1065, USA.
Nucleosides & Nucleotides
|March 6, 1999
Abstract:
Starting with commercially available tetracyanoethylene, we describe a more efficient and higher yielding synthesis of toyocamycin with regards to convenience, overall yield, and total reaction time than those syntheses previously reported.