[Evolution of granulomas induced by BCG vaccine administered in the experiment]

The time course of hepatic granulomatosis was studied on a CBAxC57B1/6 murine model of a vaccinal process induced by BCG vaccine. It was found that over the natural course of inflammation, there were changes in the spectrum of granulomas from epithelioid cellular to macrophageal and fibrotic ones with stabilization of their sizes, averaged cellular composition and density in the organ. Long-term use of isoniazid caused a considerably (2-fold) reduction in the number of granulomas in the organ and thus a decrease in the level of its fibrotic process. Presumably, in the treated animals, the mechanism responsible for a reduction in the number of granulomas is the "dissociation" of macrophageal cells from them.